Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid abnormalities in patients with myotonic dystrophy.

K S Steinbeck, J N Carter

    Clinical Endocrinology
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hypoglycaemia in cystic fibrosis in the absence of diabetes: A systematic review.

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2016
    Same author

    A candidate gene approach for identifying differential iron responses in young overweight women to an energy-restricted haem iron-rich diet.

    European journal of clinical nutrition·2014
    Same author

    Cardiovascular risk factors in elderly Koreans in Australia and Korea.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    The effect of an individual versus group program on weight loss.

    Asia Pacific journal of clinical nutrition·2014
    Same author

    Transition to adult care in adolescent obesity: a systematic review and why it is a neglected topic.

    International journal of obesity (2005)·2013
    Same author

    Higher protein diet for weight management in young overweight women: a 12-month randomized controlled trial.

    Diabetes, obesity & metabolism·2013
    Same journal

    Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH.

    Clinical endocrinology·2026
    Same journal

    Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases.

    Clinical endocrinology·2026
    Same journal

    Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome.

    Clinical endocrinology·2026
    Same journal

    Regarding Non-Classical Presentations of Rare Hereditary Hypoparathyroidism: A Case Series of CASR, GNA11, and GATA3 Mutations in Parathyroidology.

    Clinical endocrinology·2026
    Same journal

    Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort.

    Clinical endocrinology·2026
    Same journal

    Preoperative CALLY Index for Identifying Atypical Parathyroid Tumors.

    Clinical endocrinology·2026
    See all related articles

    Myotonic dystrophy (MD) patients show increased thyroid abnormalities and reduced thyroid-stimulating hormone (TSH) responses to TRH stimulation, despite normal circulating thyroid hormone levels. This suggests subtle thyroid dysfunction in MD.

    Area of Science:

    • Endocrinology
    • Genetics
    • Neuromuscular Disorders

    Background:

    • Myotonic dystrophy (MD) is a genetic disorder primarily affecting muscles.
    • Endocrine disturbances are known in MD, but thyroid involvement is poorly understood.
    • Existing data on thyroid gland function in MD are sparse and inconsistent.

    Purpose of the Study:

    • To investigate thyroid gland involvement in patients with Myotonic dystrophy.
    • To compare thyroid function and hormone levels between MD patients and healthy controls.
    • To assess the frequency of thyroid abnormalities in MD.

    Main Methods:

    • Studied twenty MD patients and twenty age- and sex-matched controls.
    • Assessed clinical thyroid status, circulating thyroid hormones (T4, T3, rT3), TSH levels, and T3 resin uptake.

    Related Experiment Videos

  • Performed TRH stimulation tests to evaluate TSH response and conducted thyroid scans.

    • Main Results:

    • All subjects were clinically euthyroid with no significant differences in circulating T4, T3, rT3, TSH, or T3 resin uptake.
    • MD patients exhibited significantly blunted TSH responses to TRH stimulation compared to controls.
    • Palpable thyroid abnormalities (multinodular goitres, single nodule) occurred in 15% of MD patients.

    Conclusions:

    • Palpable thyroid abnormalities are more frequent in MD patients than previously reported.
    • Myotonic dystrophy is associated with a reduced TSH response to TRH stimulation.
    • Circulating thyroid hormone levels are typically normal in MD patients.