The effects of sodium replacement on the responses of toad rods

1. We have investigated the effects of Na(+) substitution on the membrane potential and light responses of rods in the superfused retina of the toad, Bufo marinus.2. When all of the Na(+) in the Ringer was replaced with Li(+), the effects on the rods depended upon the external free Ca(2+) concentration ([Ca(2+)](o)). At [Ca(2+)](o) >/= 10(-6) M, the membrane potential (E(m)) hyperpolarized and light responses were greatly diminished or abolished. At [Ca(2+)](o)