The Frey syndrome: a simple, effective treatment

Area of Science:

• Neurology
• Dermatology
• Pharmacology

Background:

• Frey syndrome, characterized by gustatory sweating and flushing, is a benign yet socially distressing condition.
• Previous research has focused on identifying simple and effective treatments for Frey syndrome.

Purpose of the Study:

• To evaluate the efficacy and safety of glycopyrrolate for treating gustatory sweating and flushing.
• To compare topical glycopyrrolate with topical scopolamine in a double-blind study.

Main Methods:

• Clinical trials involving 22 patients with Frey syndrome.
• Investigational use of glycopyrrolate (roll-on lotion, solution, cream).
• Double-blind comparison of topical scopolamine (solution, cream) and glycopyrrolate formulations.

Main Results:

• 17 patients were followed for 4-5 years.
• 1% glycopyrrolate roll-on lotion and cream provided an average of three days of complete control of gustatory sweating.
• A remarkably low incidence of side effects was observed with glycopyrrolate formulations.

Conclusions:

• Topical glycopyrrolate, particularly the 1% roll-on lotion and cream, is an effective treatment for Frey syndrome.
• Glycopyrrolate demonstrates a favorable safety profile with minimal side effects for managing gustatory sweating.