[Monoclonal gammopathies of undetermined significance]

In the majority of monoclonal gammopathies it is not possible to demonstrate an association with an underlying disease related to multiple myeloma, Waldenström's macroglobulinemia, malignant lymphoma or amyloidosis. After a lapse of months to years, however, some patients will develop one of the diseases mentioned. Since no test can identify patients at risk, periodic controls of the M-component are necessary.