Gonadotropins in rats with hereditary diabetes insipidus (Brattleboro strain)

In the Brattleboro strain of rats, the genetic defect in vasopressin synthesis seems to be accompanied by a defect in the synthesis of other structurally related nonapeptides, such as the pineal arginine vasotocin which has antigonadotropic properties in animals. It was therefore tempting to investigate gonadotropin secretion in rats with hereditary hypothalamic diabetes insipidus (DI rats).