Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Receptor modulation and mast cell secretion.

D C Morrison

    The Journal of Investigative Dermatology
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Rat mast cell activation requires membrane interaction, with sustained stimulus-receptor contact crucial for secretion. Pre-exposure to low-dose stimuli primes mast cells for enhanced responses to subsequent challenges.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Isolation and characterization of a noncytotoxic mast-cell activator from cobra venom.

    Inflammation·2013
    Same author

    Preparation of endotoxin from pathogenic gram-negative bacteria.

    Methods in molecular medicine·2011
    Same author

    Alteration of surfactant proteins A and D in bronchoalveolar lavage fluid of Pneumocystis carinii pneumonia.

    Chinese medical journal·2001
    Same author

    Lipopolyamines as a therapeutic strategy in experimental Gram-negative bacterial sepsis.

    Journal of endotoxin research·2001
    Same author

    Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha.

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2001
    Same author

    Bacterial DNA and lipopolysaccharide induce synergistic production of TNF-alpha through a post-transcriptional mechanism.

    Journal of immunology (Baltimore, Md. : 1950)·2001
    Same journal

    Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

    The Journal of investigative dermatology·2026
    Same journal

    Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

    The Journal of investigative dermatology·2026
    Same journal

    Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

    The Journal of investigative dermatology·2026
    Same journal

    Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

    The Journal of investigative dermatology·2026
    Same journal

    The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

    The Journal of investigative dermatology·2026
    Same journal

    Impact of Online vs In-Person Management of Atopic Dermatitis on Quality of Life and Access to Care: A Randomized Controlled Trial.

    The Journal of investigative dermatology·2026
    See all related articles

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Mast cells play a key role in allergic and inflammatory responses.
    • Understanding mast cell activation is crucial for developing targeted therapies.

    Purpose of the Study:

    • To investigate the early events in rat peritoneal mast cell activation by noncytotoxic stimuli.
    • To elucidate the role of membrane interaction and stimulus-receptor dynamics in mast cell secretion.
    • To explore the concept of distinct receptors and biochemical pathways for different mast cell activators.
    • To examine the effect of mast cell priming on subsequent secretory responses.

    Main Methods:

    • Utilized rat peritoneal mast cells.
    • Applied various noncytotoxic mast cell stimuli.
    • Observed cellular interactions and secretory responses.

    Related Experiment Videos

  • Investigated stimulus-receptor interactions and biochemical pathways.
  • Assessed the impact of pre-exposure to stimuli.

    • Main Results:

    • Membrane interaction alone is sufficient to initiate mast cell secretion.
    • Sustained stimulus-membrane receptor interaction is necessary for maintaining the secretory response.
    • Evidence suggests distinct receptors and biochemical pathways for different mast cell activators.
    • Pretreatment with sub-threshold stimulus concentrations primes mast cells for enhanced secretion upon subsequent challenge.

    Conclusions:

    • Mast cell activation is initiated by membrane-bound events.
    • The nature and duration of stimulus-receptor interaction dictate the secretory response.
    • Mast cell activation involves specific receptor-mediated signaling pathways.
    • Mast cell priming is a significant factor influencing their responsiveness.