The determination of manganese in urine

A simple and quite sensitive methods of manganese determination in urine is proposed. The manganese level as well as the fluoride level are directly proportional to the level of these substances in plasma and it doesn't depend substantially on the diuresis. In not exposed population the manganese level of 24 +/- 4 nmol.l-1 (mean +/- +/- 2 SEM) was found, in population exposed to the manganese containing aerosole as much as 3500 nmol.l-1 without any signs of health damage. The level of 400 nmol.l-1 is suggested to be a safe biological limit. During the shift, the manganese level in urine evidently raises. The simultaneous inhalation of manganese and fluoride results in their interaction.