[Electroencephalographic changes induced by baclofen]

Electroencephalographic and clinical effects of baclofen were investigated in 46 neurological patients and 7 healthy volunteers. 27 cases showed an increase of slow EEG activity. Patients with spinal disease, brain-stem disease, disturbed vibratory sensation and also with renal insufficiency showed pronounced EEG-slowing. Baclofen depresses the activity in primary afferents and reticulocortical afferents. These effects can lead to EEG slowing. One patient developed a reversible organic brain syndrome and myoclonias with marked EEG-slowing and bilateral synchronous sharp and slow waves. This was interpreted as an epileptic stupor induced by Baclofen. The patient had renal insufficiency and accumulated Baclofen. Both conditions may have contributed to the epileptic manifestation.