Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Precise anticoagulation for routine hemodialysis.

P C Farrell, R A Ward, K Schindhelm

The Journal of Laboratory and Clinical Medicine

|August 1, 1978

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy.

Clinical and experimental immunology·2012

Same author

Amplified antigen-specific immune responses in HIV-1 infected individuals in a double blind DNA immunization and therapy interruption trial.

Vaccine·2011

Same author

Pathogens of Anoplura and Mallophaga (lice).

Bulletin of the World Health Organization·2010

Same author

Elastic and viscoelastic properties of porcine subdermal fat using MRI and inverse FEA.

Biomechanics and modeling in mechanobiology·2010

Same author

Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals.

Clinical and experimental immunology·2009

Same author

Water processing for hemodialysis. Part I: a historical perspective.

Seminars in dialysis·2009

Same journal

Studies on streptomycin; assay in body fluids.

The Journal of laboratory and clinical medicine·2010

Same journal

Gastrocolic fistula; an experimental study.

The Journal of laboratory and clinical medicine·2010

Same journal

An isolated heart perfusion system adapted to the determination of nongaseous metabolities; with sample data upon the isolated monkey heart.

The Journal of laboratory and clinical medicine·2010

Same journal

A new type of glass cage for metabolism studies.

The Journal of laboratory and clinical medicine·2010

Same journal

A simple electrocardiograph contact electrode for use with the smaller laboratory animal.

The Journal of laboratory and clinical medicine·2010

Same journal

A primary standard for the colorimetric determination of hemoglobin.

The Journal of laboratory and clinical medicine·2010

See all related articles

This study optimized heparin dosing for hemodialysis patients using a pharmacokinetic model. The model successfully reduced heparin use by an average of 38% without increasing clotting, improving anticoagulation control.

Area of Science:

Nephrology
Pharmacokinetics
Biomedical Engineering

Background:

A pharmacokinetic model for minimal heparinization in chronic hemodialysis patients was previously established by Gotch and Keen.
This model requires determining dose sensitivity (S) and the heparin elimination constant (K).
Precise control of anticoagulation during routine dialysis remains a challenge.

Purpose of the Study:

To extend the existing pharmacokinetic model for more precise anticoagulation control in chronic hemodialysis.
To evaluate the model's effectiveness in reducing heparin dosage while maintaining adequate anticoagulation.
To assess the variability of pharmacokinetic parameters (S and K) in stable dialysis patients.

Main Methods:

Measured dose sensitivity (S) and heparin elimination constant (K) in 30 stable chronic dialysis patients.

Related Experiment Videos

Calculated the mean half-life (t 1/2) of heparin based on individual rate constants.

Applied the model to adjust heparin infusion requirements based on mean S and K values over multiple dialysis sessions.

Main Results:

Significant inter-patient variability was observed in S (0.015–0.08 sec/unit) and K (0.04–1.7 hr⁻¹).
Mean heparin half-life was 0.86 ± 0.06 hr, consistent with normal subjects.
Heparin dosage was reduced by an average of 38% (range 13%–65%) in 5 patients without increased dialyzer clotting; similar results were seen in 22 other patients.

Conclusions:

The extended pharmacokinetic model effectively controls anticoagulation and reduces heparin administration in routine hemodialysis.
Despite inter-patient variability in elimination rates, the model remains applicable for optimizing heparin therapy.
Developed nomograms can aid in the clinical application of heparin modeling for anticoagulation management.