Pseudomonas aeruginosa meningitis treated with an azlocillin combination

Pseudomonas aeruginosa meningitis following trauma or surgery is associated with a high mortality rate. This high rate is explained both by tissue damage which leads to infection and by the failure of antibacterial therapy. The latter is due to the relatively resistant microorganism and the insufficient penetration of antibiotics into the CSF. We are reporting the successful therapy of a case of postoperative P. aeruginosa meningitis treated with the combination of azlocillin and gentamicin administered systemically together with intraventricular gentamicin.