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Defective chemotaxis in uremia.

P Siriwatratananonta, V Sinsakul, K Stern

The Journal of Laboratory and Clinical Medicine

|September 1, 1978

Summary

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A novel chemotactic factor inhibitor (CFI) was found in 37% of uremic patients, inactivating key immune factors. This may explain the higher infection rates observed in uremia.

Area of Science:

Immunology
Nephrology

Background:

Uremia is associated with an increased risk of infection.
The underlying mechanisms contributing to immune dysfunction in uremia are not fully understood.

Purpose of the Study:

To investigate the presence and activity of a novel chemotactic factor inhibitor (CFI) in the sera of uremic patients.
To determine the potential role of CFI in the increased susceptibility to infection in uremia.

Main Methods:

Sera from uremic patients were analyzed for the presence of inhibitory activity against leukotactic factors.
Specific immune factors including C5f, C3f, and BF were tested for inactivation by the serum factor.
Correlation of inhibitory activity with blood urea nitrogen (BUN) and creatinine levels was assessed.

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Main Results:

37% of uremic patients demonstrated the presence of CFI in their sera.
The identified serum factor irreversibly inactivated C5f, C3f, and BF.
Inhibitory activity ranged from 37% to 61% for C5f, 25% to 36% for C3f, and 28% to 51% for BF.
No correlation was found between CFI activity and BUN or creatinine levels.

Conclusions:

A novel chemotactic factor inhibitor (CFI) is present in a significant proportion of uremic patients.
CFI directly inactivates important immune mediators, potentially impairing the immune response.
The presence of CFI may contribute to the increased incidence of infections in uremic individuals.