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Synergism between N-formimidoyl thienamycin and gentamicin or tobramycin against enterococci
Antimicrobial Agents and Chemotherapy
|December 1, 1982
Abstract:
By the time-kill curve method, the combination of N-formimidoyl thienamycin and gentamicin showed synergism against 47 of 48 strains of enterococci, whereas the combination of N-formimidoyl thienamycin and tobramycin was synergistic against 46 strains.
Insights
The combination of N-formimidoyl thienamycin and gentamicin demonstrated synergistic effects against most enterococci strains. N-formimidoyl thienamycin with tobramycin also showed significant synergism in this study.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Enterococci are significant nosocomial pathogens.
- Antimicrobial resistance in enterococci necessitates combination therapy.
- N-formimidoyl thienamycin (a carbapenem) and aminoglycosides (gentamicin, tobramycin) are used against enterococcal infections.
Purpose of the Study:
- To evaluate the in vitro synergistic activity of N-formimidoyl thienamycin combined with gentamicin or tobramycin against enterococci strains.
Main Methods:
- Time-kill curve assays were employed.
- Susceptibility testing was performed on 48 strains of enterococci.
Main Results:
- The combination of N-formimidoyl thienamycin and gentamicin exhibited synergistic activity against 47 out of 48 (97.9%) enterococcal strains.
- The combination of N-formimidoyl thienamycin and tobramycin demonstrated synergistic effects against 46 out of 48 (95.8%) enterococcal strains.
Conclusions:
- Both N-formimidoyl thienamycin-gentamicin and N-formimidoyl thienamycin-tobramycin combinations show high rates of in vitro synergy against enterococci.
- These findings support the potential clinical utility of these combinations in treating enterococcal infections.