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Long term experiment of perfluorochemicals using rabbits
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1982
Summary
Perfluorochemicals (PFCs) persist in rabbit organs for two years, causing foamy cell accumulation. Liver fibrosis progresses around these cells, indicating long-term tissue changes.
Area of Science:
- Toxicology
- Histopathology
- Biomedical Research
Background:
- Previous studies reported morphological changes after Perfluorochemical (PFC) administration in rabbits.
- The long-term persistence and effects of PFCs in animal models require further investigation.
Purpose of the Study:
- To investigate the persistence of Perfluorochemicals (PFCs) and associated cellular changes in rabbits up to two years post-administration.
- To quantitatively analyze PFC retention in various organs and assess histological alterations.
Main Methods:
- Administration of a large dose of Perfluorochemicals (67 mg/kg) to rabbits.
- Histopathological examination of liver, spleen, lymph nodes, kidneys, lung, and bone marrow at two years.
- Quantitative analysis of PFC levels in different organs.
Main Results:
- Large numbers of foamy cells persisted in the liver, spleen, and lymph nodes up to two years.
- Foamy cells were also prevalent in kidneys, lung, and bone marrow.
- Quantitative analysis confirmed PFC retention in organs, with progressive fibrosis observed around foamy cells in the liver's Glisson's sheath.
Conclusions:
- Perfluorochemicals are retained in rabbit organs for at least two years.
- Long-term administration of PFCs leads to persistent foamy cell accumulation and progressive liver fibrosis.