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[Swine alveolar macrophages: description and functional analysis]
Annales De Recherches Veterinaires. Annals of Veterinary Research
|January 1, 1982
Summary
Swine alveolar macrophages (SAM) are spherical cells that adhere to surfaces and are esterase-positive but mostly peroxidase-negative. These macrophages exhibit phagocytic activity but lack cytotoxic and inhibitory functions in lymphocyte proliferation.
Area of Science:
- Immunology
- Cell Biology
Context:
- Swine alveolar macrophages (SAM) are crucial immune cells in porcine respiratory health.
- Understanding their specific functions is vital for diagnosing and treating swine respiratory diseases.
Purpose:
- To comprehensively characterize swine alveolar macrophages (SAM).
- To evaluate their adherence, cytochemical properties, phagocytic capacity, and immunological functions, including accessory roles in lymphocyte proliferation and cytotoxicity.
Summary:
- Swine alveolar macrophages (SAM) are spherical, adhere to surfaces, and are esterase-positive (85% peroxidase-negative).
- They demonstrate phagocytosis of zymosan, erythrocytes, and Listeria monocytogenes.
- SAM do not inhibit PHA-induced lymphocyte proliferation and are inactive in antibody-dependent cell-mediated cytotoxicity (ADCC), unlike swine blood monocytes.
Impact:
- Provides a detailed functional profile of SAM, essential for comparative immunology.
- Highlights differences between SAM and other mononuclear phagocytes, informing research on swine immune responses.
- Establishes baseline characteristics for future studies on porcine lung immunity and disease pathogenesis.