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LHRH analogues can be luteotrophic.

R Fleming, J R Coutts

Clinical Endocrinology

|December 1, 1982

Summary

Supraoptimal doses of LHRH analogue Hoe 766 initially boosted hormones but later caused pituitary unresponsiveness. This led to luteal phase prolongation in most women, suggesting corpus luteum sensitivity to gonadotropins.

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Area of Science:

Reproductive Endocrinology
Hormone Therapy

Background:

The LHRH analogue Hoe 766's effects on the menstrual cycle require clarification.
Previous studies suggested luteolytic (corpus luteum destroying) effects of short-term LHRH analogue treatment.

Purpose of the Study:

To investigate the impact of supraoptimal doses of the LHRH analogue Hoe 766 on hormone levels and menstrual cycle progression.
To determine if the corpus luteum remains responsive to gonadotropins during Hoe 766 therapy.

Main Methods:

Seven normally menstruating women received daily supraoptimal doses of Hoe 766 during the mid/late luteal phase.
Circulating levels of LH, FSH, oestradiol (E2), and progesterone were monitored.
Menstrual onset was tracked to assess cycle duration.

Main Results:

Initial supraoptimal Hoe 766 doses increased LH, FSH, E2, and progesterone.
The pituitary became unresponsive to Hoe 766 after a few days, with LH and FSH returning to normal luteal phase levels.
Progesterone and E2 levels remained elevated for at least 24 hours post-treatment.
Menstrual onset was delayed in five of seven women, indicating luteotrophism.

Conclusions:

The corpus luteum is responsive to increased LH/FSH during Hoe 766 therapy.
Reported luteolytic effects of short-term LHRH analogue treatment are likely due to reduced pituitary gonadotropin levels, not direct ovarian inhibition.

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