Morphological and biochemical transformation of skeletal muscle into cartilage

In summary, these studies show that the potential to form cartilage is not restricted to a defined population of limb tissues, but resides within limb mesenchyme as one of its several potencies. A theoretically novel aspect of these studies is the relative ease with which the synthesis of sulfated GAG and proteoglycan monomer may be evoked. But, what appears to control the appearance of a fully differentiated cartilage matrix is a shift from the synthesis of low molecular weight HA to species of greater molecular weight.