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Failure to show decrease in small pulmonary blood vessels in rats with experimental pulmonary hypertension.

J M Kay, K L Suyama, P M Keane

    Thorax
    |December 1, 1982
    PubMed
    Summary
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    This study found that the number of small pulmonary blood vessels did not decrease in rats with pulmonary hypertension induced by chronic hypoxia or monocrotaline. These findings challenge previous assumptions about vessel loss in pulmonary hypertension.

    Area of Science:

    • Cardiovascular Research
    • Pulmonary Medicine
    • Animal Models

    Background:

    • Pulmonary hypertension is characterized by increased pressure in the pulmonary arteries.
    • The role of small pulmonary blood vessel density in the pathogenesis of pulmonary hypertension is debated.
    • Existing models of pulmonary hypertension include chronic hypoxia and monocrotaline administration.

    Purpose of the Study:

    • To investigate the density of small pulmonary blood vessels in rat models of pulmonary hypertension.
    • To determine if chronic hypoxia or monocrotaline administration leads to a reduction in small pulmonary blood vessels.
    • To compare vessel density in induced pulmonary hypertension with control groups.

    Main Methods:

    • Chronic pulmonary hypertension was induced in rats via hypobaric hypoxia or monocrotaline injection.

    Related Experiment Videos

  • Right ventricular systolic blood pressure and hypertrophy were measured.
  • Histological lung sections were analyzed to count small pulmonary blood vessels (<50 microns diameter).

    • Main Results:

    • Rats with hypoxia-induced pulmonary hypertension showed a trend towards a higher total number of small pulmonary blood vessels compared to controls.
    • No significant difference in the number of small pulmonary blood vessels per mm² was observed between hypoxic rats and controls.
    • Rats with monocrotaline-induced pulmonary hypertension exhibited similar total numbers and density of small pulmonary blood vessels compared to controls.

    Conclusions:

    • The number of small pulmonary blood vessels is not reduced in rats with pulmonary hypertension induced by chronic hypoxia.
    • Monocrotaline-induced pulmonary hypertension in rats does not result in a decreased number of small pulmonary blood vessels.
    • These findings suggest that pulmonary hypertension may develop without a loss of small pulmonary blood vessels.