[Preoperative OMF therapy for gastric cancer--examination of macroscopical effect in comparison with histological...

OMF treatment consisting of perifocal administration of OK-432 associated with treatment with MMC and 5-FU was applied for 14 lesions of 13 cases including 1 case of multiple cancer. The results obtained were examined macroscopically and histologically. Macroscopic findings were rated as "good" in 5 lesions (35.8%), "fair" in 8 lesions (57.1%) and "poor" in 1 case. There was no significant difference according to a histologic type. Histologic efficacy was assessed as "++" for 6 lesions (43%), "+" for 6 lesions (43%) and "-" for 2 lesions (14%), suggesting a tendency that higher histologic efficacy be obtained for lesions with a lower degree of differentiation. Taking "+" or higher histologically as "effective", the efficacy rate was approximately 86%. When the macroscopic results were compared with histologic results based on a criteria for assessment established by our group, it was found that the macroscopic efficacy tended to be associated with the histologic efficacy with a consistency rate of approximately 71%.