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[Renal cell carcinoma].

T Machida, F Masuda

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Aggressive treatment, including chemotherapy, is recommended for renal cell carcinoma with pulmonary metastasis. Early detection within two years improves outcomes, with some patients surviving over five years post-treatment.

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    Area of Science:

    • Oncology
    • Medical Research

    Context:

    • Investigated 42 cases of renal cell carcinoma (RCC) with pulmonary metastasis.
    • Pulmonary metastasis occurred initially in 18 cases and post-nephrectomy in 24 cases.
    • 83% of pulmonary metastases were detected within 2 years of primary lesion treatment.

    Purpose:

    • To clinically investigate the pathological state and treatment methods for RCC with pulmonary metastasis.
    • To evaluate the efficacy of various treatment modalities for pulmonary metastasis.
    • To determine survival rates and identify prognostic factors.

    Summary:

    • Surgery offered prolonged survival in 1 of 2 cases. Radiotherapy achieved complete remission in 1 of 4 cases.
    • Chemotherapy showed objective improvement in 14% (3 of 21 cases), with a 3-drug combination showing promise.

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  • Hormonal therapy demonstrated no remission in metastatic lesions. Overall 1- and 3-year survival rates were 32% and 16% respectively.

    • Impact:

    • Despite limited chemotherapy response rates, aggressive treatment, including chemotherapy, is deemed preferable for managing pulmonary metastasis in RCC.
    • Four out of 42 patients survived over 5 years post-treatment, indicating potential benefits of aggressive management.
    • Findings support further research into optimizing chemotherapy regimens for metastatic RCC.