Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular folate binding proteins; function and significance.

C Wagner

    Annual Review of Nutrition
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Paclitaxel plus cetuximab for the treatment of R/M SCCHN after first-line pembrolizumab failure: primary analysis from the PaceAce trial.

    ESMO open·2026
    Same author

    Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

    Physical review letters·2026
    Same author

    Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

    Physical review letters·2025
    Same author

    Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same author

    The role of environmental impact in healthcare providers' choices of inhalers for treatment of asthma and COPD: a discrete choice experiment.

    BMC primary care·2025
    Same author

    Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

    Physical review letters·2025
    Same journal

    Mechanisms of NAD+ Homeostasis in Aging and Disease.

    Annual review of nutrition·2026
    Same journal

    Metabolite Damage and Repair in Health and Disease.

    Annual review of nutrition·2026
    Same journal

    From Food to Function: Cross-Kingdom Transfer and Regulatory Potential of Dietary microRNAs Highlighted by Breast Milk.

    Annual review of nutrition·2026
    Same journal

    The Influence of Diet on Cancer Progression and Treatment.

    Annual review of nutrition·2026
    Same journal

    The Potential Physiologic Mechanisms by Which Early-Life Nutrition May Influence Type 2 Diabetes Pathophysiology in Humans.

    Annual review of nutrition·2026
    Same journal

    The Paradox and Future of GLP-1/GIP Combination Therapies: Efficacy and Mechanisms.

    Annual review of nutrition·2026
    See all related articles

    Cellular folate binding proteins likely transport folate into cells. Intracellular proteins, like those in liver cytosol, may serve storage or enzymatic roles, though definitive proof is challenging.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Molecular Biology

    Background:

    • Cellular folate binding proteins (FBPs) are implicated in folate metabolism.
    • Understanding the precise functions of these proteins is crucial for cellular health.

    Purpose of the Study:

    • To elucidate the specific functions of various cellular folate binding proteins.
    • To investigate the roles of membrane-bound and intracellular FBPs.

    Main Methods:

    • Analysis of protein localization and function in both bacterial (L. casei) and mammalian cell systems.
    • Utilizing mutant strains to study transport and binding defects.
    • Investigating the enzymatic activities of intracellular FBPs in rat liver mitochondria.

    Main Results:

    Related Experiment Videos

    • Membrane-bound FBPs are suggested to facilitate folate transport into cells.
    • Bacterial systems offer clearer insights into FBP transport roles due to easier mutant generation.
    • Intracellular FBPs identified in liver, with mitochondrial FBPs identified as enzymes (dimethylglycine dehydrogenase, sarcosine dehydrogenase).
    • Cytosolic FBP-CII is proposed to have a storage function, though direct evidence is difficult to obtain.

    Conclusions:

    • Specific functions can be assigned to cellular folate binding proteins with some certainty.
    • Membrane-associated FBPs likely play a role in folate uptake.
    • Intracellular FBPs may possess enzymatic activities or serve storage functions, particularly in the liver.