[Bacteriological study on cefadroxil in vitro. Correlation between diameter of inhibition zone and inhibitory...

There are only slight differences between the geometrical means of minimum inhibitory concentrations of (6R,7R)-7-[(R)-2-amino-2-2(p-hydroxyphenyl)-acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cefadroxil, Bidocef) and cefalexin against gram-positive and gram-negative bacteria freshly isolated from clinical material. Enterococci are more susceptible to cefadroxil. Considering the different break point, cefadroxil is on the whole more effective than cefalexin, in particular so against Proteus mirabilis, Enterobacter, Citrobacter and Escherichia coli. With the aid of the described regression analysis a meaningful interpretation of the results of the cefadroxil agar diffusion test is possible.