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Effect of Morphine and butorphanol on gallbladder emptying
Canadian Journal of Surgery. Journal Canadien De Chirurgie
|January 1, 1983
Summary
Butorphanol is a better pain reliever for biliary tract and pancreatic pain than morphine. It minimally affects gallbladder emptying, making it a suitable choice for patients experiencing this type of pain.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Biliary tract and pancreatic pain management requires careful analgesic selection.
- Opioid analgesics can affect gastrointestinal motility, complicating treatment.
Purpose of the Study:
- To compare the effects of morphine and butorphanol on gallbladder function.
- To determine the most suitable analgesic for biliary and pancreatic pain.
Main Methods:
- Gallbladder contraction and emptying were stimulated using cholecystokinin octapeptide.
- The effects of morphine and butorphanol on these processes were measured.
Main Results:
- Morphine significantly inhibited gallbladder emptying.
- Butorphanol only slightly delayed gallbladder emptying.
- Butorphanol demonstrated a minimal effect compared to morphine.
Conclusions:
- Butorphanol appears to be a more suitable analgesic for managing biliary tract and pancreatic pain.
- The minimal impact of butorphanol on gallbladder function supports its use in these patient populations.