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Related Experiment Videos

Postirradiation neurofibrosarcoma.

B S Ducatman, B W Scheithauer

    Cancer
    |March 15, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Radiation therapy can induce secondary neurofibrosarcomas, a rare cancer of peripheral nerves. Patients with von Recklinghausen

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    Area of Science:

    • Oncology
    • Radiation Oncology
    • Pathology

    Background:

    • Radiation therapy is a known risk factor for secondary neoplasms, including sarcomas.
    • Neurofibrosarcoma, a malignancy of peripheral nerves, is an emerging post-irradiation neoplasm.
    • This tumor is often associated with von Recklinghausen's disease.

    Purpose of the Study:

    • To investigate the occurrence of neurofibrosarcoma secondary to radiation therapy.
    • To analyze clinicopathologic features and outcomes of radiation-induced neurofibrosarcoma.

    Main Methods:

    • Clinicopathologic review of 109 neurofibrosarcoma cases at the Mayo Clinic (1912-1981).
    • Identification of tumors arising in previously irradiated areas.
    • Analysis of patient history, including von Recklinghausen's disease and radiation exposure.

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    Main Results:

    • Twelve of 109 neurofibrosarcoma cases originated in previously irradiated sites.
    • Seven of these 12 patients had von Recklinghausen's disease.
    • Mean latency period was 15.6 years; 8 patients recurred, 2 had metastases, and 9 died from the disease.

    Conclusions:

    • Neurofibrosarcoma can arise secondary to radiation therapy, supported by animal studies.
    • Patients with von Recklinghausen's disease should avoid unnecessary irradiation.
    • Vigilant observation for secondary neurofibrosarcoma is crucial in patients receiving radiation therapy.