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Cardiac abnormalities in mixed connective tissue disease.

W J Oetgen, M L Mutter, O J Lawless

    Chest
    |February 1, 1983
    PubMed
    Summary

    Mixed connective tissue disease (MCTD) patients often show cardiovascular issues like pericarditis. Noninvasive tests reveal a high prevalence of cardiac abnormalities in these individuals.

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    Area of Science:

    • Cardiology
    • Rheumatology
    • Internal Medicine

    Background:

    • Mixed connective tissue disease (MCTD) is an autoimmune disorder with diverse clinical manifestations.
    • Cardiovascular involvement is a recognized but not fully characterized complication of MCTD.

    Purpose of the Study:

    • To assess the prevalence and types of cardiovascular abnormalities in patients with MCTD using noninvasive techniques.
    • To identify the most common cardiac findings in this patient population.

    Main Methods:

    • Noninvasive cardiovascular diagnostic methods were employed.
    • Electrocardiography (ECG) and echocardiography were utilized to evaluate cardiac structure and function.

    Main Results:

    • Cardiovascular abnormalities were detected in 38% of the 16 MCTD patients studied.
    • Common findings included pericarditis, asymmetric septal hypertrophy, and left ventricular (LV) dilatation.
    • Borderline abnormalities were noted in 31%, while 31% showed normal results across all techniques.
    • Steroid-responsive pericarditis was the most frequent clinical abnormality, observed in 25% of cases.

    Conclusions:

    • MCTD patients exhibit a significant prevalence of cardiovascular abnormalities detectable by noninvasive methods.
    • Pericarditis, often responsive to steroids, is a key cardiac manifestation in MCTD.
    • Routine noninvasive cardiac evaluation may be warranted for patients diagnosed with MCTD.

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