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Recovery of Paramyxovirus from the jejunum of patients with multiple sclerosis
Lancet (London, England)
|May 28, 1977
Abstract:
Paramyxovirus, presumably measles, has been recovered by cocultivation or cell-fusion techniques from jejunal biopsy specimens of 6 consecutive patients with multiple sclerosis. Virus has been identified by immunofluorescence of antigen in infected HEp-2 and BSC-1 cells, by electron microscopy, and by haemagglutination of rhesus-monkey erythrocytes.
Insights
Measles virus, a type of paramyxovirus, was found in 6 multiple sclerosis patients. The virus was identified using cell cultures, immunofluorescence, electron microscopy, and hemagglutination tests.
Area of Science:
- Virology
- Neurology
- Immunology
Background:
- Multiple sclerosis (MS) is a chronic neurological disease with an unclear etiology.
- Viral infections are suspected as potential triggers or contributors to MS pathogenesis.
Purpose of the Study:
- To investigate the potential presence of paramyxoviruses, specifically measles virus, in patients diagnosed with multiple sclerosis.
Main Methods:
- Jejunal biopsy specimens from 6 consecutive MS patients were analyzed.
- Virus recovery was achieved through cocultivation and cell-fusion techniques.
- Virus identification involved immunofluorescence, electron microscopy, and hemagglutination assays.
Main Results:
- Paramyxovirus, presumed to be measles, was successfully recovered from all 6 patients.
- The presence of viral antigen was confirmed in infected cell lines (HEp-2, BSC-1).
- Electron microscopy and hemagglutination further supported virus identification.
Conclusions:
- These findings suggest a potential association between measles virus and multiple sclerosis.
- Further research is warranted to elucidate the role of this paramyxovirus in MS.