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Related Experiment Videos

Effects of spinal tractotomy on spatial sequence recognition in macaques.

C J Vierck, R H Cohen, B Y Cooper

    The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
    |February 1, 1983
    PubMed
    Summary

    The dorsal columns are crucial for recognizing the order of tactile stimuli on the hindlimb. Lesions here cause significant deficits, though training can lead to recovery.

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    Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat.

    Neuroscience·2016

    Area of Science:

    • Neuroscience
    • Somatosensation
    • Tactile Perception

    Background:

    • The dorsal column (DC) pathway is essential for processing tactile information, including spatial and sequential aspects.
    • Understanding the specific roles of different spinal cord tracts in tactile sequence recognition is crucial for neuroscience research.

    Purpose of the Study:

    • To investigate the role of different spinal cord white matter tracts in tactile sequence recognition in non-human primates.
    • To determine the critical pathways for processing the order of tactile stimuli applied to the hindlimb.

    Main Methods:

    • Five Macaca speciosa monkeys were trained to discriminate tactile stimulus order on their lateral calf.
    • Psychophysical thresholds were measured by varying the distance between stimulated points.

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  • Lesions were made to specific spinal cord tracts, including the fasciculus gracilis, lateral, ventral, and dorsolateral columns.
  • Postoperative thresholds and recovery were assessed over several months.

    • Main Results:

    • Complete interruption of the ipsilateral fasciculus gracilis significantly elevated tactile sequence recognition thresholds.
    • Recovery of normal discrimination was observed after training following fasciculus gracilis lesions.
    • Lesions to the lateral and ventral columns caused only mild, transient deficits.
    • Isolation of the ipsilateral dorsolateral column (ILC) or contralateral ventral quadrant (CVQ) resulted in substantial, enduring deficits in tactile sequence recognition.

    Conclusions:

    • The dorsal columns, particularly the fasciculus gracilis, play a critical role in hindlimb tactile sequence recognition.
    • The dorsal columns are more critical for this function than the lateral or ventral columns.
    • Spatiotactile sequence recognition relies heavily on the integrity of the dorsal column pathway.