Related Experiment Video
Updated: Aug 12, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Abstract:
We undertook a retrospective analysis of the incidence of acute rheumatic fever (ARF) in Memphis-Shelby County during the five-year period from 1977 through 1981. Cases were identified by review of local hospital records and by mail and telephone communication with 327 primary care physicians and neurologists. Forty-one patients met the modified Jones criteria, of whom 16 had conditions that were diagnosed in Memphis but who resided elsewhere. The overall ARF incidence among Memphis-Shelby County residents was 0.64 cases per 100,000 population each year. The highest rate, 3.74, was found among blacks aged 5 to 17 years residing in the inner city, while white children in the suburban and rural areas had a rate of only 0.49. Current strategies for prevention and diagnosis of ARF must take into account the extraordinarily low level to which the incidence of the disease has fallen in certain suburban US populations.
Insights
Acute rheumatic fever (ARF) incidence in Memphis-Shelby County was low overall, but significantly higher in inner-city Black children aged 5-17. Suburban white children showed a much lower ARF rate.
Area of Science:
- Epidemiology
- Public Health
Background:
- Acute rheumatic fever (ARF) is a serious complication of untreated streptococcal infections.
- Understanding ARF incidence is crucial for public health strategies and resource allocation.
Purpose of the Study:
- To determine the incidence of acute rheumatic fever (ARF) in Memphis-Shelby County from 1977 to 1981.
- To identify demographic and geographic disparities in ARF rates.
Main Methods:
- Retrospective analysis of hospital records.
- Physician and neurologist surveys (n=327) via mail and telephone.
- Case identification using modified Jones criteria.
Main Results:
- Overall ARF incidence was 0.64 cases per 100,000 population annually.
- The highest incidence rate (3.74 per 100,000) was observed in Black children aged 5-17 in the inner city.
- White children in suburban and rural areas had a significantly lower rate (0.49 per 100,000).
Conclusions:
- ARF incidence has fallen to very low levels in some US populations, particularly suburban white children.
- Prevention and diagnostic strategies need to consider the declining and disparate incidence of ARF.
- Targeted public health interventions may be necessary for high-risk populations.
Related Concept Videos
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Rheumatic Heart Disease III: Medical Management
Rheumatic Heart Disease IV: Nursing Management
Rocky Mountain Spotted Fever

