Kinetics of amyloid deposition. I. The effects of amyloid-enhancing factor and splenectomy

It has long been recognized that amyloid AA deposition occurs in two phases, a predeposition and a deposition phase. The deposition phase has two distinct periods, a period of rapid deposition followed by a plateau stage. This kinetic pattern is seen in both liver and spleen and in animals in which the appearance of AA is accelerated by the administration of amyloid-enhancing factor. Amyloid-enhancing factor recipients have a shorter lag period before AA deposition is evident, but the kinetics of deposition and tissue level attained are similar to that seen in nonrecipients. It is also demonstrated that amyloid-enhancing factor activity may be generated in the liver of splenectomized animals.