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Related Experiment Videos

Abuse of amitriptyline.

M J Cohen, R Hanbury, B Stimmel

    JAMA
    |September 22, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Amitriptyline (Elavil) misuse is common in patients undergoing methadone maintenance. A study found 25% admitted using it for euphoria, with 34% testing positive for the drug in urine samples.

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    Area of Science:

    • Pharmacology
    • Addiction Medicine
    • Clinical Psychology

    Background:

    • Amitriptyline hydrochloride (Elavil) is a common antidepressant for mild to moderate depression.
    • Patients in methadone maintenance programs may be at higher risk for substance misuse.

    Purpose of the Study:

    • To investigate the prevalence of amitriptyline misuse among individuals in a methadone maintenance program.
    • To assess the self-reported and confirmed use of amitriptyline for non-medical purposes.

    Main Methods:

    • A survey was conducted among 346 patients in a methadone maintenance program.
    • Urine specimens were analyzed using thin-layer chromatography over a five-month period.
    • Data on self-admitted amitriptyline use for euphoria were collected.

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    Main Results:

    • 86 out of 346 patients (25%) admitted to taking amitriptyline to achieve euphoria.
    • 34% of patients tested positive for amitriptyline in urine specimens at least once during the study period.
    • A significant discrepancy between self-reported use and confirmed presence of amitriptyline was observed.

    Conclusions:

    • Misuse of amitriptyline is a notable issue within the studied population.
    • Prescribers should exercise caution when prescribing amitriptyline to individuals dependent on narcotics.
    • Further research is warranted to understand the motivations and patterns of amitriptyline misuse in this demographic.