Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low urinary citrate excretion in nephrolithiasis.

M J Nicar, C Skurla, K Sakhaee

    Urology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Not Available].

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
    Same author

    [Not Available].

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
    Same author

    [Not Available].

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
    Same author

    Role of medical approach in the management of stone disease.

    International journal of urology : official journal of the Japanese Urological Association·2013
    Same author

    The effects of smoking on bone metabolism.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2012
    Same author

    Comparison of the absorption of calcium carbonate and calcium citrate after Roux-en-Y gastric bypass.

    Obesity surgery·2009

    Over half of patients with kidney stones have low urinary citrate excretion (hypocitraturia). This condition was prevalent across most stone types, excluding primary hyperparathyroidism and hyperuricosuric calcium oxalate nephrolithiasis.

    Area of Science:

    • Nephrology
    • Urology
    • Biochemistry

    Background:

    • Nephrolithiasis, or kidney stones, affects a significant portion of the population.
    • Urinary citrate plays a crucial role in inhibiting calcium stone formation.
    • Understanding the prevalence and causes of low urinary citrate is vital for stone management.

    Purpose of the Study:

    • To investigate the prevalence of low urinary citrate excretion (hypocitraturia) in patients diagnosed with nephrolithiasis.
    • To analyze the occurrence of hypocitraturia across various patient subgroups categorized by specific physiologic or metabolic abnormalities.

    Main Methods:

    • Patient categorization based on distinct physiologic or metabolic abnormalities.
    • Measurement and analysis of urinary citrate excretion levels in all patient cohorts.

    Related Experiment Videos

    Main Results:

    • A high prevalence of hypocitraturia was observed, affecting over 50% of patients with kidney stones.
    • Hypocitraturia was identified in most categories, including renal tubular acidosis, enteric hyperoxaluria, absorptive hypercalciuria, and renal hypercalciuria.
    • Notably, hypocitraturia was absent in primary hyperparathyroidism and hyperuricosuric calcium oxalate nephrolithiasis patient groups.

    Conclusions:

    • Low urinary citrate excretion is a common finding in patients with nephrolithiasis.
    • Hypocitraturia is present in various metabolic conditions leading to kidney stones, even when acid-base disturbances are excluded.
    • Identifying hypocitraturia is important for understanding the pathophysiology of nephrolithiasis in diverse patient populations.