Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clostridium difficile cytotoxin in a pediatric population.

C M Thompson, P H Gilligan, M C Fisher

    American Journal of Diseases of Children (1960)
    |March 1, 1983
    PubMed
    Summary

    Clostridium difficile cytotoxin was found in 8.6% of pediatric patients, particularly in younger children and those with hospital or antibiotic-associated illnesses. These factors were significant independent risks for C. difficile infection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Addressing the dual-use of antifungals and fungal antimicrobial resistance (fAMR) through a One Health approach.

    npj antimicrobials and resistance·2026
    Same author

    Development of a Polymerase Chain Reaction Protocol for Detection of <i>Xylella fastidiosa</i> in Plant Tissue.

    Phytopathology·2025
    Same author

    Novel amplified fragment length polymorphism (AFLP) markers for typing medically relevant <i>Fusarium</i> and allied fusarioid genera.

    Fungal systematics and evolution·2025
    Same author

    What happens post-pilot testing? A model for revising a disability awareness and competency training program.

    Disability and health journal·2024
    Same author

    Trends in the molecular epidemiology and population genetics of emerging <i>Sporothrix</i> species.

    Studies in mycology·2022
    Same author

    Racism and Older Black Americans' Health: a Systematic Review.

    Journal of urban health : bulletin of the New York Academy of Medicine·2022

    Area of Science:

    • Microbiology
    • Pediatric Infectious Diseases
    • Gastroenterology

    Background:

    • Clostridium difficile is a significant cause of infectious diarrhea in children.
    • Cytotoxin production is a key virulence factor for C. difficile.
    • Understanding risk factors for C. difficile cytotoxin in pediatric populations is crucial for effective management.

    Purpose of the Study:

    • To determine the prevalence of Clostridium difficile cytotoxin in pediatric stool samples.
    • To identify risk factors associated with the presence of C. difficile cytotoxin in children.
    • To correlate C. difficile cytotoxin detection with clinical diagnoses in pediatric patients.

    Main Methods:

    • Stool samples from 208 pediatric patients were analyzed for Clostridium difficile cytotoxin.

    Related Experiment Videos

  • Data on patient age, hospitalization, and antibiotic use were collected.
  • Clinical diagnoses were reviewed for correlation with cytotoxin detection.

    • Main Results:

    • Clostridium difficile cytotoxin was detected in 8.6% of pediatric patients.
    • Cytotoxin was more prevalent in younger children (median age 11 months).
    • Hospital-associated illness (17%) and antibiotic-associated illness (18%) were linked to higher cytotoxin detection rates.

    Conclusions:

    • Younger age, hospitalization, and antibiotic use are significant independent risk factors for C. difficile cytotoxin in pediatric patients.
    • C. difficile cytotoxin can be associated with a spectrum of clinical presentations, from colitis to asymptomatic carriage.
    • Routine laboratory assays for C. difficile cytotoxin are valuable in pediatric settings.