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Related Experiment Videos

Reference serum pepsinogen concentrations in dairy cattle.

J D Harvey-White, J P Smith, E Parbuoni

    American Journal of Veterinary Research
    |January 1, 1983
    PubMed
    Summary

    Higher serum pepsinogen levels in yearling heifers may indicate parasitic infection. This study established baseline concentrations to aid in diagnosing ostertagiasis in grazing calves.

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    Area of Science:

    • Veterinary Parasitology
    • Ruminant Health
    • Biochemistry

    Background:

    • Ostertagiasis is a significant parasitic disease affecting cattle, particularly young animals.
    • Accurate diagnosis is crucial for effective treatment and herd management.
    • Serum pepsinogen concentration is a potential biomarker for abomasal damage caused by Ostertagia ostertagi.

    Purpose of the Study:

    • To determine baseline serum pepsinogen concentrations in yearling heifers and lactating cows.
    • To establish a threshold for serum pepsinogen concentration indicative of potential ostertagiasis in yearling calves.

    Main Methods:

    • Serum samples were collected from 27 yearling heifers and 50 lactating cows.
    • Pepsinogen concentration was measured using a spectrophotometric assay, reported in ng/ml and mU of tyrosine/ml.

    Main Results:

    • Yearling heifers had a mean serum pepsinogen concentration of 44 ± 12 ng/ml.
    • Lactating cows had a lower mean concentration of 20 ± 8 ng/ml.
    • A serum pepsinogen level exceeding 68 ng/ml in yearling calves grazing on pasture suggests further examination for ostertagiasis.

    Conclusions:

    • Serum pepsinogen concentration differs between age groups of cattle.
    • Elevated serum pepsinogen in yearling calves may serve as an early indicator of ostertagiasis.
    • This biomarker can assist in identifying animals requiring diagnostic workup for parasitic gastroenteritis.

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