Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimating eighth nerve survival by electrical stimulation.

L Smith, F B Simmons

    The Annals of Otology, Rhinology, and Laryngology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Passive constriction of the upper airway during central apneas: fiberoptic and EMG investigations.

    Respiration physiology·1997
    Same author

    Lassa fever and sudden hearing loss.

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·1993
    Same author

    High-powered automobile stereos.

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·1993
    Same author

    Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells.

    Blood·1992
    Same author

    A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets.

    European journal of pharmacology·1992
    Same author

    Gamma probe location of 111indium-labeled B72.3: an extension of immunoscintigraphy.

    Journal of surgical oncology·1992
    Same journal

    Laryngeal Injuries Following General Endotracheal Anesthesia: A Case Series.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Clinical and Voice Outcome Differences in Vocal Cord Cysts with and Without Sulcus Vocalis: Insights From a Tertiary Center in Saudi Arabia.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Bioabsorbable Stenting in a Case of Severe Pediatric Posterior Glottic Stenosis.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Efficacy and Safety of Finafloxacin Otic Suspension, 0.3% for the Treatment of Acute Otitis Externa: Results from two Phase III Randomized Clinical Studies.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Evaluation Of the Expression Levels Of SerpinB3/B4/B10, Interleukin-17 As Biomarkers For Chronic Rhinosinusitis With Nasal Polyps.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Correlation of Patient-Reported Symptoms With Rhinogram Features Beyond Simple Airway Resistance.

    The Annals of otology, rhinology, and laryngology·2026
    See all related articles

    Loudness growth, not threshold, reliably indicates surviving auditory nerve fibers after cochlear implant surgery. This electrical auditory brainstem response (eABR) growth predicts nerve survival, crucial for patient selection and outcome prediction.

    Area of Science:

    • Neuroscience
    • Otolaryngology
    • Biomedical Engineering

    Background:

    • Assessing auditory nerve survival is critical for cochlear implant patient selection and predicting surgical outcomes.
    • Current methods for determining nerve survival may not be sufficiently accurate.

    Purpose of the Study:

    • To investigate the relationship between auditory nerve fiber survival and electrically evoked auditory brainstem response (eABR) characteristics.
    • To identify reliable predictors of ganglion cell survival in cochlear implant candidates.

    Main Methods:

    • Auditory nerve fibers were deliberately degenerated in 17 feline cochleas to create varying degrees of cell loss.
    • Electrical auditory brainstem response (eABR) input-output functions were recorded from stimulated cochleas.
    • Correlation between eABR parameters and the percentage of surviving ganglion cells was analyzed.

    Related Experiment Videos

    Main Results:

    • No eABR activity was observed in cochleas with complete ganglion cell loss.
    • Cochleas with 5%-10% surviving cells showed normal thresholds but reduced eABR input-output functions.
    • The slope of the suprathreshold eABR input-output function reliably predicted ganglion cell survival across all degeneration levels.

    Conclusions:

    • Electrical threshold is an unreliable indicator of auditory nerve survival.
    • Loudness growth, reflected in the eABR input-output function slope, is a strong predictor of surviving ganglion cells.
    • This finding has significant implications for optimizing cochlear implant candidacy and post-operative outcome prediction.