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Aprindine therapy for refractory ventricular tachycardia
Archives of Internal Medicine
|February 1, 1983
Summary
Aprindine hydrochloride effectively treated refractory ventricular tachycardia in five of seven patients. While neurologic side effects were manageable, one patient developed agranulocytosis, a rare but serious adverse event.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Aprindine hydrochloride is a European antiarrhythmic agent.
- It has shown success in managing refractory arrhythmias.
Purpose of the Study:
- To evaluate the efficacy and safety of aprindine hydrochloride.
- To assess its use in patients with ventricular tachycardia refractory to standard treatments.
Main Methods:
- Retrospective case series.
- Review of seven patients with ventricular tachycardia treated with aprindine hydrochloride.
Main Results:
- Aprindine was effective in 5 out of 7 patients.
- Neurologic side effects were common but manageable with dose adjustment.
- One patient experienced agranulocytosis, a rare serious side effect.
Conclusions:
- Aprindine hydrochloride can be an effective option for refractory ventricular tachycardia.
- Careful monitoring for side effects, particularly agranulocytosis, is crucial.