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Hyperthyroidism and familial hypertrophic cardiomyopathy
Insights
Hyperthyroidism may cause hypertrophic cardiomyopathy (HC). Treating hyperthyroidism in one patient resolved HC symptoms, suggesting antithyroid therapy could be beneficial for this heart condition.
Area of Science:
- Cardiology
- Endocrinology
- Genetics
Background:
- Investigating a family with a high prevalence of hypertrophic cardiomyopathy (HC).
- Assessing the co-occurrence of clinical hyperthyroidism in affected family members.
Observation:
- Two to three family members exhibited both hypertrophic cardiomyopathy and hyperthyroidism.
- The primary patient (propositus) showed resolution of HC indicators after hyperthyroidism treatment.
Findings:
- A significant correlation between hyperthyroidism and hypertrophic cardiomyopathy was observed.
- Treatment of hyperthyroidism led to the reversal of clinical, ECG, and vectorcardiographic signs of HC in the propositus.
Implications:
- Antithyroid therapy may be a viable treatment option for specific cases of hypertrophic cardiomyopathy.
- Further research into the link between thyroid disorders and cardiomyopathy is warranted.
Abstract:
A kindred with a high incidence of hypertrophic cardiomyopathy (HC) was studied to identify the presence of clinical hyperthyroidism. Two and possibly three members with HC had associated hyperthyroidism. In the propositus, clinical, ECG, and vectorcardiographic evidence for HC resolved after treatment of the hyperthyroidism. We hypothesize that the disproportionately high correlation of hyperthyroidism and HC and the resolution found in the propositus after treatment may indicate that antithyroid therapy should be considered in this form of cardiomyopathy.