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Wound healing accelerated by Staphylococcus aureus.

S M Levenson, D Kan-Gruber, C Gruber

    Archives of Surgery (Chicago, Ill. : 1960)
    |March 1, 1983
    PubMed
    Summary
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    Staphylococcus aureus significantly accelerates wound healing and increases wound strength in rats. This effect, observed across multiple strains, surpasses that of other known healing agents.

    Area of Science:

    • Microbiology
    • Wound Healing Research
    • Biomedical Science

    Background:

    • Traditional wound healing research explores various physical and chemical agents.
    • The role of bacterial inoculation in modulating wound healing remains an area of investigation.

    Purpose of the Study:

    • To investigate the effect of Staphylococcus aureus (S. aureus) inoculation on the rate of wound healing and gain in wound strength in a rat model.
    • To compare the effects of S. aureus with other bacterial species and previously reported wound healing enhancers.

    Main Methods:

    • Rat skin incisions were inoculated with S. aureus.
    • Wound strength was measured postoperatively over 28 days.
    • Histological examination was performed to assess for infection.
    • Different strains of S. aureus, Staphylococcus epidermidis, Staphylococcus hominis, and Pseudomonas aeruginosa were tested.

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    Main Results:

    • S. aureus inoculation dramatically accelerated wound healing and increased wound strength, with effects evident from postoperative day four and maximal at seven to ten days.
    • The accelerating effect correlated with the number of S. aureus organisms introduced.
    • No gross signs of infection were observed; occasional microabscesses were seen histologically.
    • Seven strains of S. aureus demonstrated this effect, while S. epidermidis, S. hominis, and P. aeruginosa did not.
    • The observed increases in wound healing were substantially greater than those reported for nutritional supplements, drugs, or other agents.

    Conclusions:

    • Staphylococcus aureus possesses a potent wound-healing accelerating effect in rats.
    • This effect is strain-dependent and significantly outperforms previously studied interventions.
    • Potential local and systemic mechanisms underlying this phenomenon warrant further investigation.