[Microcirculation of the lungs in histamine administration after vagotomy]

Intravital microscopy was used to study the microcirculatory bed of the lungs during application of histamine after righthand vagotomy. It was discovered that responses occurring at that level during histamine application after intersection of the right vagus were not equivalent to those when the biologically active substance was used in intact animals. Application of histamine without intersection of the nerve was characterized by aggravation of microcirculatory disorders in the lungs as the drug concentration was raised. The reverse was observed in cases where histamine was applied after righthand vagotomy. In this case the most significant alterations in the microcirculatory bed were recorded after local use of low doses of histamine. Besides, the duration of their occurrence was more prolonged as compared to that seen during histamine application in intact animals.