[Interaction of synthetic peptides with the individual components of the blood coagulation system]

Spectrophotometry and viscosimetry were used to examine the interaction of taftcin and its decomposition products with individual components of the blood coagulation system. Peptides with free amino groups at the N-end were found to form complexes with heparin. The presence of free carboxylic groups at the C-end provided for their interaction with fibrinogen. In both the cases, the leading roles are played by electrostatic forces that determine the weakness of the effects seen. Taftcin has a negligible antipolymerization activity at the expense of the Pro-Arg sequence presence at the C-end.