Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spontaneous heteroploidy in one-cell mouse embryos.

P A Martin-DeLeon, M L Boice

    Cytogenetics and Cell Genetics
    |January 1, 1983
    PubMed
    Summary

    This study analyzed mouse zygotes, finding that chromosome 19 is frequently involved in aneuploidy. Female nondisjunction contributed to trisomy, while male factors influenced monosomy and dispermy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Germ-cell hyaluronidases: their roles in sperm function.

    International journal of andrology·2011
    Same author

    Spam1 (PH-20) mutations and sperm dysfunction in mice with the Rb(6.16) or Rb(6.15) translocation.

    Mammalian genome : official journal of the International Mammalian Genome Society·2002
    Same author

    Assignment of the parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR1) to rabbit chromosome band 9p14-->p13 by fluorescence in situ hybridization.

    Cytogenetics and cell genetics·2001
    Same author

    Mouse epididymal Spam1 (PH-20) is released in vivo and in vitro, and Spam1 is differentially regulated in testis and epididymis.

    Biology of reproduction·2001
    Same author

    Lack of sharing of Spam1 (Ph-20) among mouse spermatids and transmission ratio distortion.

    Biology of reproduction·2001
    Same author

    Mouse Spam1 (PH-20): evidence for its expression in the epididymis and for a new category of spermatogenic-expressed genes.

    Journal of andrology·2000

    Area of Science:

    • Reproductive biology
    • Cytogenetics
    • Mammalian developmental biology

    Background:

    • Chromosome abnormalities in early mammalian development can lead to developmental issues.
    • Understanding the origins of these anomalies is crucial for reproductive health research.

    Purpose of the Study:

    • To investigate the frequency and parental origin of chromosome anomalies in early mouse zygotes.
    • To assess the utility of the outbred Swiss mouse as a model for studying cytogenetic anomalies.

    Main Methods:

    • Analysis of chromosome banding in 321 zygotes from superovulated ICR mice.
    • Determination of ploidy, aneuploidy (trisomy, monosomy, triploidy), and structural rearrangements.
    • Parental origin determination using differential chromosome condensation.

    Main Results:

    • 87% diploidy observed; aneuploidy (trisomy, monosomy, triploidy) occurred at frequencies of 3.6%, 2.5%, and 0.93% respectively.
    • Chromosome 19 was most frequently involved in aneuploidy.
    • Female nondisjunction accounted for 1.5% of trisomy cases, while male factors contributed to monosomy and dispermy.

    Conclusions:

    • The outbred Swiss mouse model is valuable for studying factors inducing cytogenetic anomalies.
    • Both paternal and maternal factors contribute to chromosome anomalies in early mammalian development.
    • Specific chromosomes, like 19, may be more susceptible to nondisjunction events.

    Related Experiment Videos