Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic hepatitis induced by alcohol.

J Nei, Y Matsuda, A Takada

    Digestive Diseases and Sciences
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Chronic hepatitis in heavy drinkers can stem from alcohol or other causes. Alcohol-induced chronic hepatitis improves with abstinence and shows distinct clinical and histological features, potentially progressing to cirrhosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Human thrombin and calcium bound factor Xa significantly shorten tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity.

    Thrombosis and haemostasis·1998
    Same author

    Effects of electric footshock and water immersion restraint stresses on fibrinolytic parameters in the plasma of rats.

    Thrombosis research·1998
    Same author

    Proteolysis of highly polysialylated NCAM by the tissue plasminogen activator-plasmin system in rats.

    Neuroscience letters·1998
    Same author

    Remnant-like particle cholesterol is a major risk factor for myocardial infarction in vasospastic angina with nearly normal coronary artery.

    Atherosclerosis·1998
    Same author

    Severe heat stroke associated with high plasma levels of plasminogen activator inhibitor 1.

    Burns : journal of the International Society for Burn Injuries·1998
    Same author

    Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II.

    Pathology international·1998

    Area of Science:

    • Hepatology
    • Immunology
    • Toxicology

    Background:

    • Heavy alcohol consumption is a significant cause of liver disease.
    • Chronic hepatitis presents diagnostic challenges, especially in differentiating alcohol-related causes from others.
    • Understanding the specific mechanisms of alcohol-induced liver injury is crucial for effective management.

    Purpose of the Study:

    • To investigate the characteristics of chronic hepatitis in heavy drinkers.
    • To differentiate alcohol-induced chronic hepatitis from non-alcohol-related chronic hepatitis.
    • To explore the immunopathological aspects and progression of alcohol-induced chronic hepatitis.

    Main Methods:

    • Studied 15 heavy drinkers with histological features of chronic hepatitis.
    • Analyzed clinical features, serum liver enzyme ratios (GOT/GPT), glutamate dehydrogenase activity, and leukocyte migration inhibition tests.

    Related Experiment Videos

  • Examined liver histology for characteristic changes and followed cases for progression to cirrhosis.

    • Main Results:

    • Alcohol-induced chronic hepatitis showed improvement with abstinence, distinct GOT/GPT ratios, and high glutamate dehydrogenase.
    • Leukocyte migration inhibition tests for ethanol were frequently positive in alcohol-induced cases.
    • Histology revealed combined features of chronic hepatitis and alcoholic fibrosis; 3 of 4 cases progressed to cirrhosis.

    Conclusions:

    • Alcohol-induced chronic hepatitis is a distinct entity within alcoholic liver disease, possibly with immunopathological underpinnings.
    • It shares features with other alcoholic liver injuries and differs from non-alcohol-related chronic hepatitis.
    • This condition represents a significant step towards the development of liver cirrhosis in heavy drinkers.