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Early reports on drug interactions.

P F D'Arcy

    Drug Intelligence & Clinical Pharmacy
    |February 1, 1983
    PubMed
    Summary

    Early drug interaction reports in medical literature serve as vital warnings for healthcare professionals. This review highlights potential drug-drug interactions, encouraging further research to confirm their clinical significance.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Drug Safety

    Background:

    • Correspondence and brief reports in medical journals are crucial for identifying potential drug-drug interactions.
    • These early reports act as an essential early warning system for clinicians and pharmacists.
    • A literature review from the first half of 1982 identified several such reports.

    Purpose of the Study:

    • To provide wider publicity for early reports of drug-drug interactions.
    • To encourage further observation and research to validate these potential interactions.
    • To alert practitioners to potential drug hazards.

    Main Methods:

    • A survey of medical literature published in the first half of 1982.
    • Identification and compilation of early reports on drug-drug interactions.
    • Review of anecdotal and potentially coincidental reports.

    Main Results:

    • Several potential drug-drug interactions were identified from the literature survey.
    • Interactions reviewed include amiodarone-quinidine, lidocaine-prenylamine, erythromycin-carbamazepine, azapropazone-phenytoin, chlordiazepoxide-levodopa, gentamicin-furosemide, ethanol-aspirin, acetaminophen-coumarin anticoagulant, and cimetidine-lidocaine.
    • The reports varied in certainty, from anecdotal to potentially coincidental.

    Conclusions:

    • Early reports, though sometimes preliminary, are valuable for highlighting potential drug interactions.
    • Further research is needed to establish the validity and clinical significance of these reported interactions.
    • Practitioners should be aware of these potential drug hazards and remain vigilant.

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