[Action of gamma-aminobutyric acid on central and peripheral sympathetic mechanisms]

Acute experiments were made on cats to record bioelectrical responses in T3, L2-4, white rami, and in postganglionic sympathetic branches that innervate blood vessels of the skin and skeletal muscles under stimulation of segmental nerves and descending vasopressor pathways. The GABA effects on the sympathetic nervous system were dissimilar, suggesting different sites of the inhibitory and activation effects of the drug in central (specific action) and peripheral (adrenergic action) components of the system.