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Updated: Aug 18, 2026

GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
Published on: July 17, 2011
[Hemodynamic mechanism of the hypotensive action of beta-phenyl-GABA esters (phenibut)]
Abstract:
It was established in acute and chronic experiments on cats that phenibut ethers are 7-10 times more potent than phenibut itself as regards hypotensive activity and produce inconsistent effects on the cardio- and hemodynamics. Of these ethers, methyl ether of phenibut is the most powerful agent. It causes lasting hypotension when given in doses of 1/50 and 1/30 of the LD50 at the cost of a decrease in the general peripheral resistance. At the same time, apart from raising the blood inflow to the heart and cardiac output, the drug has a compensated adverse ino- and chronotropic action on the heart.
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