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Changes in nucleosomal core histone variants during chicken development and maturation.

M K Urban, A Zweidler

    Developmental Biology
    |February 1, 1983
    PubMed
    Summary

    Chicken core histone variants H2A, H2B, and H3 change during development and maturation. Their proportions are linked to growth rate, not cell differentiation, with H3.3 increasing significantly in adult tissues.

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    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Molecular Biology

    Background:

    • Core histones (H2A, H2B, H3) exist as primary structure variants.
    • These variants are found in varying proportions across different adult chicken tissues.

    Purpose of the Study:

    • To quantitatively analyze chicken core histone variants during embryonic development and posthatching maturation.
    • To investigate the relationship between histone variant proportions and growth rate versus cell differentiation.

    Main Methods:

    • Polyacrylamide gel electrophoresis in nonionic detergents to resolve histone variants.
    • Quantitative analysis of histone components throughout chicken development.

    Main Results:

    • H2A variants remain in similar proportions throughout development and in adult tissues.

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  • H2B and H3 variants show developmental changes, with a second variant appearing and increasing.
  • Posthatching, minor H2B and H3 variant levels differ based on tissue mitotic activity; H3.3 becomes predominant in non-dividing adult tissues.

    • Conclusions:

    • Changes in chicken core histone variant proportions correlate with growth rate, not cell differentiation.
    • Replication-independent incorporation likely explains the increase of H3.3 in adult, non-dividing cells.