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Updated: Aug 9, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Vascular effects of glucocorticosteroids, with special reference to budesonide
Abstract:
The effect of glucocorticosteroids was tested on in vitro responses of tension developed by strips of umbilical blood vessels. 1. Hydrocortisone, methylprednisolone and dexametasone in concentrations of 10(-4)-10(-3) mainly inhibited spontaneous tone. Hydrocortisone and methylprednisolone induced a biphasic response with an initial small contraction followed by a more long lasting relaxation. 2. Budesonide, a novel powerful, non-halogenated steroid only induced a long lasting contraction. 3. The relaxation with hydrocortisone was of the same magnitude as after indomethacine, therefore, this response may be due to inhibition of prostaglandin-synthesis. 4. There was no leftward shift of the dose response curve to catecholamine stimulation but rather a slightly higher maximal response. There is no clear evidence of a uptake-2 blockade in our preparation.
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