Hypoxic and embolic pulmonary vasoconstriction
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Updated: Aug 14, 2026

Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
Published on: January 14, 2014
Abstract:
In-vitro studies of helically-cut segmental pulmonary artery strips from 43 patients undergoing thoracic surgery were performed. Cumulative dose-response contraction curves were elicited, mean maximum contraction was significantly greater from histamine (Hist) than from prostaglandin F2 alpha (PGF2 alpha), serotonin (5-HT), angiotensin II (A II) or noradrenaline (NA). Hist and PGF2 alpha showed significantly lower values for ED50 than NA, 5-HT and A II. Anoxia did not constrict the isolated arteries.
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