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Asteroid bodies--an ultrastructural study.

H Miller, B Miller, H Rabinowitz

    Investigative Ophthalmology & Visual Science
    |January 1, 1983
    PubMed
    Summary
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    Asteroid bodies in the vitreous humor, linked to vision loss in asteroid hyalosis, show a liquid crystalline structure. These structures contain calcium and phosphorus, suggesting they are phospholipid liquid crystals, not true crystals.

    Area of Science:

    • Ophthalmology
    • Biophysics
    • Materials Science

    Background:

    • Asteroid hyalosis is an ocular condition characterized by the presence of yellowish-white, spherical bodies in the vitreous humor.
    • This condition can lead to visual impairment, including blurred vision and vision loss.
    • The exact ultrastructural composition and nature of these asteroid bodies have been a subject of ongoing research.

    Observation:

    • This study presents an ultrastructural examination of asteroid bodies obtained via vitreous aspiration.
    • High-resolution transmission electron microscopy revealed a distinct lamellar arrangement within the asteroid bodies.
    • A periodicity of 4.6 nm was measured for this lamellar structure.

    Findings:

    • The observed lamellar arrangement is characteristic of liquid crystalline phases typically formed by lipids in aqueous environments.

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  • X-ray micro-analysis confirmed the presence of calcium and phosphorus within the asteroid bodies.
  • The findings suggest that asteroid bodies are not true crystals but rather liquid crystals composed of phospholipids.

    • Implications:

    • This research provides a novel understanding of the composition and structure of asteroid bodies.
    • The identification of a liquid crystalline phospholipid structure may open new avenues for investigating the pathogenesis of asteroid hyalosis.
    • Further research could explore potential therapeutic strategies targeting these liquid crystalline structures to improve visual function in affected patients.