Kinetics of replication of lactate dehydrogenase-elevating virus in age-dependent polioencephalomyelitis
Related Experiment Video
Updated: Oct 12, 2026

Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
Abstract:
The kinetics of replication of lactate dehydrogenase-elevating virus (LDV) in age-dependent polioencephalomyelitis was studied in genetically susceptible (C58/J) and resistant (C57BL/6J) mice. The peripheral replication pattern (plasma concentration) for LDV was similar in both strains. However, the concentration of virus within the central nervous system was strikingly different. In nonsusceptible C57BL/6J mice, little or no virus was found within the central nervous system. In the lumbar cord of susceptible C58/J mice, an increase in the concentration of LDV began 5 days postinfection and continued during the preclinical stages of disease. A direct correlation was shown between the concentration of LDV in spinal cord and the appearance of motor neuron disease but not the degree of inflammatory reaction.
Related Concept Videos
Size and Structure of Viral Genomes
Viral Replication: Lytic Cycle
Viral Replication: Lysogenic Cycle
Poliomyelitis
Rabies
Encephalitis ll: Pathophysiology

