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Spreading pigmented actinic keratosis.

P Subrt, J L Jorizzo, P Apisarnthanarax

    Journal of the American Academy of Dermatology
    |January 1, 1983
    PubMed
    Summary
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    Spreading pigmented actinic keratoses are a recently described skin lesion found in sun-exposed areas. Histologically, they show actinic keratosis with excess melanin, appearing as a brown patch or plaque.

    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Actinic keratosis (AK) is a common precancerous skin lesion.
    • Pigmented variants of AK are increasingly recognized.
    • Understanding pigmented AK is crucial for early cancer detection.

    Observation:

    • Four cases of spreading pigmented actinic keratoses (SPAK) were identified.
    • SPAK presents as a brown patch or plaque on sun-exposed skin.
    • Lesions are typically smooth-surfaced and larger than 1 cm, spreading centrifugally.

    Findings:

    • Histopathology reveals features of AK with excessive melanin deposition.
    • Melanin is found in the lower epidermis and upper dermis.
    • Clinical differential diagnoses include seborrheic keratosis, nevi, lentigos, and melanoma.

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    Implications:

    • SPAK may be more prevalent than current literature suggests.
    • Accurate diagnosis of SPAK is essential to differentiate from melanoma.
    • Recognition of SPAK aids in timely management of precancerous skin lesions.