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Related Experiment Videos

Age-associated changes in human epidermal cell renewal.

G L Grove, A M Kligman

    Journal of Gerontology
    |March 1, 1983
    PubMed
    Summary
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    Skin cell renewal slows significantly with age, taking longer for epidermal cells to reach the surface in older adults. This decline accelerates after age 50, indicating reduced skin cell proliferation.

    Area of Science:

    • Dermatology and aging research
    • Cell biology and epidermal kinetics
    • Human physiology and skin aging

    Background:

    • Epidermal cell renewal is crucial for maintaining skin integrity and function.
    • Age-related changes in skin cell turnover can impact skin health and appearance.
    • Noninvasive methods for assessing epidermal kinetics are valuable for dermatological studies.

    Purpose of the Study:

    • To investigate the effect of aging on epidermal cell renewal in humans.
    • To quantify changes in stratum corneum transit time with age.
    • To determine the relationship between epidermal cell proliferation and age.

    Main Methods:

    • Utilized a noninvasive fluorescence-based assay using dansyl chloride.
    • Monitored the disappearance rate of the fluorescent marker from the skin surface.

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  • Assessed epidermal cell renewal in a cohort of young and older adult volunteers.

    • Main Results:

    • Stratum corneum transit time was approximately 20 days in young adults.
    • Older adults exhibited an extended transit time, over 10 days longer than younger adults.
    • The data suggest diminished epidermal cell proliferation in older individuals, as horny cell layer thickness remained constant.

    Conclusions:

    • Epidermal cell renewal significantly decreases with age, particularly after 50.
    • A linear-spline model may better represent age-related decline in cell renewal than a simple linear model.
    • These findings highlight age-associated alterations in skin cell kinetics and proliferation.